American Society for Clinical Pathology (ASCP) Histotechnologist Practice Test

Why is Glyoxal preferred in some laboratories over formaldehyde?

1. It is more effective in fixing carbohydrates

2. It is less toxic

3. It provides better color preservation

4. It penetrates tissues more slowly

The correct answer is: It is less toxic

Glyoxal is often preferred in certain laboratories due to its lower toxicity compared to formaldehyde. Formaldehyde is a well-known irritant and can pose serious health risks, including respiratory problems and carcinogenicity, making it less desirable in settings where prolonged exposure might occur. In contrast, glyoxal has a reduced risk of these effects, allowing for safer handling in laboratory environments. Additionally, while glyoxal might also have specific advantages in terms of fixing properties and tissue preservation, its primary appeal in many labs remains its lower toxicity profile. This factor can be critical in creating a safer working environment for histotechnologists and supporting staff, thus enhancing overall laboratory safety practices.